WebGO:0044210 'de novo' CTP biosynthetic process Cellular Component: GO:0005829 cytosol: Descriptions from all associated GenBank mRNAs : AK025654 - Homo sapiens cDNA: FLJ22001 fis, clone HEP06629. BC034986 - Homo sapiens CTP synthase II, mRNA (cDNA clone MGC:32997 IMAGE:5268973), complete cds. CTP (cytidine triphosphate) synthetase catalyzes the last committed step in pyrimidine nucleotide biosynthesis: ATP + UTP + glutamine → ADP + Pi + CTP + glutamate It is the rate-limiting enzyme for the synthesis of cytosine nucleotides from both the de novo and uridine salvage pathways. The reaction proceeds by the … See more CTP synthase is an enzyme (EC 6.3.4.2) involved in pyrimidine biosynthesis that interconverts UTP and CTP. See more Active CTP synthase exists as a homotetrameric enzyme. At low enzyme concentrations and in the absence of ATP and UTP, CTP synthase exists as inactive monomer. As enzyme concentration increases, it polymerizes first to a dimer (such as the form … See more CTP synthase has been reported to form filaments in several different organisms. These include bacteria (C. crescentus), yeast ( See more • Pyrimidine biosynthesis See more Two isozymes with CTP synthase activity exist in humans, encoded by the following genes: • See more CTP synthase is precisely regulated by the intracellular concentrations of CTP and UTP, and both hCTPS1 and hCTPS2 have been seen to be maximally active at physiological concentrations of ATP, GTP, and glutamine. The activity of … See more Upregulated CTP synthase activity has been widely seen in human and rodent tumors. Mutations in the … See more
Human Gene CTPS2 (ENST00000443824.5) - BLAT
WebCTP synthase 1 là enzyme ở người được mã hóa bởi gen CTPS. Chức năng. Enzyme cytidine-5-prime-triphosphate synthetase xúc tác quá trình biến đổi uridine triphosphate (UTP) thành cytidine triphosphate (CTP). Enzyme này đóng vai ... WebBiological Process: CTP biosynthetic process Source:GO_Central. 1 publication. Biological Process: glutamine metabolic process Source:UniProtKB-KW. Biological … lic book
Human Gene CTPS2 (ENST00000359276.9) Description and Page …
WebMar 21, 2024 · NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3) is a Protein Coding gene. Diseases associated with NME3 include Lipase Deficiency, Combined and Heinz Body Anemias.Among its related pathways are purine nucleotides de novo biosynthesis and pyrimidine deoxyribonucleotides biosynthesis from CTP.Gene Ontology (GO) … WebCTP biosynthetic process Source:UniProtKB. 1 publication. Biological Process: glutamine metabolic process Source:UniProtKB-KW. Biological Process: nucleobase-containing compound metabolic process Source:ProtInc. 1 publication. Biological Process: pyrimidine nucleobase biosynthetic process Source:GO_Central. WebGene Ontology Term: GTP biosynthetic process. GO ID. GO:0006183. Aspect. Biological Process. Description. The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. mckee funeral home obituaries baker wv