High dose ara-c

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WebThirty-two patients with untreated ALL (n = 26) or lymphoblastic lymphoma (n = 6) between 17 and 65 years of age were treated with a short remission induction course with VP16 … Web21 de set. de 2005 · Intervention Model: Parallel Assignment. Masking: None (Open Label) Primary Purpose: Treatment. Official Title: Efficacy of 6x R-CHOP Followed by Myeloablative Radiochemotherapy and Autologous Stem Cell Transplantation vs. 3 x (R-CHOP/R-DHAP) Followed by a High Dose ARA-C Containing Myeloablative Regimen …

Ara-C fever and infections after high-dose ara-C treatment in …

WebCytosine Arabinoside. Cytosine arabinoside (Ara-C or cytarabine) is used for hematological malignancies, breast cancer, and occasionally is given intrathecally for leptomeningeal carcinomatosis. High-dose Ara-C causes a reversible cerebellar syndrome in 10% to 20% of patients. It usually starts a few days after treatment, peaks at 2 to 3 days ... Web20 de nov. de 2024 · Alternatively, a higher dose of 3.0mg/kg daunorubicin and 75mg/kg Ara-C was used (high dose DA therapy). For some experiments, doxorubicin was … can herpes show up months later

Pixantrone for the treatment of adult patients with relapsed or ...

WebCytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia ... Rarely, myelopathy has been reported after high … WebHigh-dose cytarabine (HD araC) therapy resulted from a theoretical model developed in the 1970s that attempted to maximize the anti-leukemia effect of cytarabine. Since that time, … Web1 de dez. de 2015 · Since May 1986, we have treated 98 patients with acute myeloid leukemia (AML) on a protocol consisting of induction with mitoxantrone (10 mg/m2) for 4 days and cytosine arabinoside (Ara-C) (100 mg ... fit for one raunheim

Chemotherapy Induces Senescence-Like Resilient Cells Capable of ...

Curative chemotherapy for acute myeloid leukemia: the ... - Springer

Web16 de nov. de 2006 · Methods: The DHAC regimen consists of Dexamethasone at 15mg/m 2 /dose po every 6 hours × 10 doses, High-dose Ara-C at 3gr/m 2 (1.5gr/m 2 if >50 yrs old) iv over 3 hrs every 12 hrs for 4 doses and Carboplatin at 200mg/m 2 iv every 24 hrs for 2 doses. When utilized, ... Web1 de jun. de 2024 · High-dose Ara-C–treated conditions (≥1,000 nmol/L) were measured after one month of recovery (C). D, Scheme demonstrating that patient-derived AML cells (AML2928) treated with a case-dependent high dose of Ara-C (3 days × 500 nmol/L) and re-treated after recovery from nadir. fit for oneWebThe objective of this study was to examine the incidence and characteristics of Ara-C-related fever and the frequency and severity of infections after single-drug, high-dose … can herpes sores appear anywhere on the body

"WebThe aim of this study is to determine whether the addition of mitoxantrone to high dose cytarabine improves the outcome of treatment in patients ... Patients achieving complete … " - High dose ara-c

High dose ara-c

WebA multicentric prospective pilot study using three different schedules of high-dose Ara-C at dosage of 3 g/m2 every 12 hours during 3 h of infusion was undertaken by the Italian … Web9 de out. de 2014 · The optimal dose, scheme, and clinical setting for Ara-C in acute myeloid leukemia (AML) treatment remain uncertain. In this study, we performed a meta …

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Web28 de abr. de 2013 · A neurological assessment guide has helped nurses to assess and document the use of high-dose cytarabine, according to research presented at the ONS 38th Annual Congress. WebNotably, almost all of the patients included had previously received a median cumulative doxorubicin-equivalent dose ranging from 292.9 mg/m 2 to 315 mg/m 2, below the limit of 400–500 mg/m 2 conventionally considered the safety limit to prevent anthracycline-related cardiotoxicity, 34 even if several studies have shown a linear correlation between doses …

Web25 de ago. de 2024 · Cytarabine (Ara-C) in consolidation therapy played important role in preventing relapses for AML patients achieved complete remission, but the optimum … Web30 de mai. de 2024 · e18513 Background: FN is an anticipated complication of consolidation with HiDAC for AML, though precise descriptions of incidence, type, and severity of …

Web11 de abr. de 2024 · The total duration of treatment with Venetoclax will be 6 days (day -11 to -6 before stem cell infusion). Patients with active disease at transplant will receive a 3 … Web11 de abr. de 2024 · The total duration of treatment with Venetoclax will be 6 days (day -11 to -6 before stem cell infusion). Patients with active disease at transplant will receive a 3-day ramp-up prephase of Ara-C (100mg total dose infused in 1h) with daily increasing doses of Venetoclax to prevent TLS during conditioning.

WebAn understanding of the cellular pharmacology, cytokinetics and pharmacokinetics of ara-C in leukemic mice showed substantial schedule-dependency. Exposure to high doses for a short duration (C × t) resulted in a palliative therapeutic outcome. In marked contrast, exposure to lower doses for a protracted period (c × T) was curative.

WebPurpose: To determine the impact of high-dose cytarabine (ARA-C) (HDAC) dose modification, based on renal function, on the incidence of neurotoxicity (NT). Patients … can herpes simplex cause meningitisWebHigh-dose cytarabine (HD ARA-C) has been extensively used in relapsed acute myeloid leukemia (AML), either alone [1] or in combination with asparaginase [2], daunorubicin (DNR) [3], amsacrine (AMSA) [4], or mitoxantrone [5]. With this high-dose regimen (3 g/m 2 twice daily for 4–6 days), high remission reinduction rates have been achieved ... fit for ordinary purpose janger pdfWeb6 de jan. de 2024 · We developed a polygenic score consisting of 10 SNPs,designated as ACS10, that not only provides prognostic significance by predicting poor outcome in acute myeloid leukemia, but suggests that alternative treatment strategies with either high-dose ara-C or addition of gemtuzumab ozogamicin are more suitable strategies for patients … can herpes simplex 1 be transmitted sexuallyWeb1 de jan. de 1988 · Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone (DHAP) WS Velasquez, WS Velasquez Department of Hematology, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston 77030. can herpes simplex affect earsWeb13 de nov. de 2024 · In the control arm A, patients receive an alternating R-CHOP/R-DHAP induction followed by myeloablative consolidation (either BEAM or THAM: TBI, high dose Ara-C and melphalan). In arm A+I Ibrutinib is added to the R-CHOP cycles (560 mg day 1-19) and applied as maintenance (continuous dosing) for 2 years. can herpes show up in a blood testWeb16 de ago. de 2024 · ALL induction followed by Blinatumomab and high-dose Ara-C prior to HSCT: CR for 24 months post HSCT CR for 8 months post HSCT CR 5 months post HSCT: Li et al. 29-year-old male with B/myeloid CD19+ MPAL and SET-NUP14 fusion gene transcript: ALL induction followed by hybrid Consolidation (hyper-CVAD-B and hyper … fit for one by bonnieWeb11 de abr. de 2024 · Currently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, … can herpes simplex 1 turn into type 2