Webb25 nov. 2024 · Conclusion. Tetrazole, the bioisoster of carboxylic acid, is an important pharmacophore in the development of novel drugs. Tens of tetrazole-containing compounds, such as cefamandole, ceftezole, tedizolid, letrozole, encequidar, oteseconazole, quilseconazole, losartan, valsartan, irbesartan, candesartan and … Webb1 jan. 2014 · The design concept was based on the premise that the amide NH of 264 would mimic the H-bond donor properties of the dihydropyridine NH of 262 while the …
Amide Bond Bioisosteres: Strategies, Synthesis, and Successes
Webb27 jan. 2024 · Simple strategy towards amide bioisosteres By Malcolm P. Huestis Nature.com 2024-01-27 Read full article on original website What are your thoughts? … Webb20 juli 2024 · Bioisosterism is widely employed in the rational modification of lead compounds, being used to increase potency, enhance selectivity, improve … solicitor bradford on avon
Simple strategy towards amide bioisosteres Article Information
WebbChairman/ Head ,Medicinal and Process Chemistry Division , Chief Scientist and Professor AcSIR. Chemical Sciences, CSIR-Central Drug Research Institute (CDRI), Lucknow-India . … Webb12 nov. 2024 · Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. The amide functional group plays a key role in the composition of biomolecules, including many … WebbFor compound, are the inhibitors of several receptors including: example, the selectivity is of no importance when dealing (1) NS3 protease, important for treatment of hepatitis C … solicitor agent right of audience lpc law